Oats (Avena sativa) reduce atherogenesis in LDL-receptor-deficient mice
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چکیده
منابع مشابه
Augmented Atherogenesis in LDL Receptor Deficient Mice Lacking Both Macrophage ABCA1 and ApoE
AIM ABCA1 protects against atherosclerosis by facilitating cholesterol efflux from macrophage foam cells in the arterial wall to extracellular apolipoprotein (apo) A-I. In contrast to apoA-I, apoE is secreted by macrophages and can, like apoA-I, induce ABCA1-mediated cholesterol efflux. Yet, the combined effect of macrophage ABCA1 and apoE on lesion development is unexplored. METHODS AND RESU...
متن کامل12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice.
BACKGROUND Human 15-lipoxygenase (LO) and its murine analogue 12/15-LO are capable of directly oxidizing esterified fatty acids in lipoproteins and phospholipids. Because these oxidized products possess atherogenic properties, it was suggested that LOs may be involved in enhancing atherogenesis. Previous in vivo tests of the role of LOs in atherogenesis animal models, however, have yielded conf...
متن کاملSubcellular Localization of Proteases in Developing Leaves of Oats (Avena sativa
The distribution and subcellular localization of the two major proteases present in oat (Avena sativa L. cv Victory) leaves was investigated. Both the acidic protease, active at pH 4.5, and the neutral protease, active at pH 7.5, are soluble enzymes; a few percent of the enzyme activity was ionically bound or loosely associated with organellar structures sedimenting at 1000g. On the average, 16...
متن کاملChiasma frequency, distribution and terminalization in hexaploid oats (Avena sativa L.)
Chiasma counting has been regarded as the most straightforward method of scoring the total number of crossing-over events in the genome. In organisms in which genetic analysis is difficult or impossible to perform, it is a good estimator of the level of genetic recombination. In this paper we evaluated the chiasma frequency and distribution at diakinesis of twelve Brazilian oat varieties (Avena...
متن کاملThe Spectrum of Major Seed Storage Genes and Proteins in Oats (Avena sativa)
BACKGROUND The oat seed storage proteins are mainly composed of two classes: the globulins and avenins. Among the major cereals, the globulins are the major seed protein class in rice and oats, and along with the higher protein content of oats is the basis for the relative higher nutrition content in oats compared to the other cereals. The second major class of oat seed proteins is the avenins;...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2010
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2010.05.001